In contrast to GA-analogue effects on tumours driven by other RTK oncogenes, however, TrkAIII exerts a negative impact upon GA-induced NB cell eradication, increasing TrkAIII ER-accumulation, resulting in rapid attenuation UPR-associated Ire1a/Xbp-1 activation and enhanced survival, when compared to control and TrkA transfectants. The gene discussed is NTRK1; the disease is neuroblastoma.