In addition to NBs, human glioblastoma multiforme tumours also express TrkAIII, including an EGFR and EGFRvIII negative subpopulation, suggesting that TrkAIII represents a potential oncogenic alternative to EGFR and EGFRvIII oncogenes in this tumour type [23]. The gene discussed is EGFR; the disease is Nijmegen breakage syndrome.