TrkAIII promotion of pro-survival and pro-angiogenic PI3K/Akt/NF-кB signaling exhibited by TrkAIII transfectants suggests that inhibitors of PI3K/Akt/NF-кB signaling could significantly slow tumour progressions, reduce tumour-associated angiogenesis and enhance chemotherapeutic-sensitivity. This evidence concerns the gene AKT1 and neoplasm.