NTRK1 and cancer: The capacity of alternative splicing to unlock TrkA oncogenic potential, characterises sequence encoded within exons 6–7 in preventing oncogenic activation, the deletion of which causes receptor re-localization and spontaneous activation within altered intracellular substrate contexts, resulting in a plethora of “addiction” and “non-addiction” oncogenic mechanisms that impact upon a majority of the Hallmarks of Cancer (Schematized in Figs. 7 and 9).