NTRK1 and cancer: This suggests that cancers driven by TrkAIII may also represent good candidates for small molecule therapeutic Trk tyrosine kinase inhibitors, such as Larotrectinib, Entrectinib, Cabozantinib, Merestinib, TRS-011, DS-6051b, MGCD516, PLX7486 and DCC-2710, currently employed in ongoing clinical trials for cancers driven by novel Trk-fusions or altered Trk activity ([11, 12] and reviewed in [17]) or novel Trk inhibitors in development, for which patents have been issued [69].