Several diagnostic models, such as the classic aminotransferase to platelet ratio index (APRI) (aspartate aminotransferase [AST]  × 100/platelet count) [9], the Forns index [10], the Fibrotest [11], the Shanghai liver fibrosis group (SLFG) model [12], Ho’s model (α2-macroglobulin, vitamin D binding protein, and apolipoprotein A1) [13] and the S index [γ-glutamyltransferase (GGT), platelet count, and albumin (ALB)] [14], have been used to diagnose liver fibrosis with high accuracy, sensitivity and specificity. The gene discussed is APOA1; the disease is Hepatic fibrosis.