After co-culture of SUM159PT or SK-BR-3 cells with adipocytes, increased expression of ATGL and HSL was detected, as well as diminished TG content and increased release of free glycerol over time, implying induction of lipolysis and ATGL-mediated utilization of accumulated lipids, which were mainly used to promote tumor invasion. Here, PNPLA2 is linked to neoplasm.