Further experiments of immunofluorescence assay and western blotting partially revealed that, the interaction with adipocytes promoted transportation of FAs into nucleus in breast cancer cells by upregulated FABP5 to activate PPARβ/δ, then induce EMT and secretion of MMP-2 to facilitate migration ad invasion possibly through activation of EGFR/MAPK signaling pathway. Here, EGFR is linked to breast cancer.