Moreover, multivariate analysis revealed that low level expression of RECQL mRNA was an independent unfavorable factor for DRFS and DSS (DRFS: adjusted HR: 3.04, 95% CI: 1.89–4.87, P < 0.001; DSS: adjusted HR: 4.25, 95% CI: 2.12–8.46, P < 0.001) in these 774 patients after adjustment for tumor size, diagnosis age, ER status, PR status, HER2 status, histological grade, lymph node status and adjuvant therapy (Table 3). This evidence concerns the gene PGR and neoplasm.