ESR1 and neoplasm: Moreover, multivariate analysis revealed that low level expression of RECQL mRNA was an independent unfavorable factor for DRFS and DSS (DRFS: adjusted HR: 3.04, 95% CI: 1.89–4.87, P < 0.001; DSS: adjusted HR: 4.25, 95% CI: 2.12–8.46, P < 0.001) in these 774 patients after adjustment for tumor size, diagnosis age, ER status, PR status, HER2 status, histological grade, lymph node status and adjuvant therapy (Table 3).