Moreover, a multivariable analysis revealed that the low level of RECQL protein expression was an independent unfavorable factor for DRFS (adjusted HR: 2.12, 95% CI, 1.16–3.88; P = 0.015) in these 322 patients after adjustment for age of diagnosis, lymph node status, PR status, ER status, HER2 status, tumor size and adjuvant therapy (Table 4). Here, PGR is linked to neoplasm.