Expression of none of these genes was consistently changed by more than two-fold in any of the cell lines (Fig. 4c), indicating that the effect of NF-κB on gene expression does not depend on MAP3K7. We conclude that in T-ALL cell lines, MAP3K7 is not required for the degradation of IκB and subsequent activation of NF-κB after stimulation with TNF-α. The gene discussed is NFKB1; the disease is acute lymphoblastic leukemia.