NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive: In prostate cancer cells and chronic myelogenous leukemia cells, the cytotoxic results indicate that heteronemin induced both the intrinsic and extrinsic pathways and cell apoptosis was mediated by Met/STAT3 pathway in prostate cancer [32] and NF-κB pathway in chronic myelogenous leukemia cells [22].