Furthermore, the Bcl-2 family of proteins (Figure S6), also involved in apoptosis, were quantified, and we observed that both cancer cell types showed a dose-dependent increase in the expression of pro-apoptotic Bax, and a concomitant decrease in anti-apoptotic Bcl-2 protein, leading to a dramatic increase in the Bax/Bcl-2 ratio (Western blots in Figure 3C and quantitation in Figure S6). The gene discussed is BAX; the disease is cancer.