Granulin family members are involved in tumorigenesis and wound healing due to their modulatory effects on cell growth [96,97,98,99] Using a proteomic approach, Yeh and colleagues identified progranulin as a novel STAT3-interacting protein in triple-negative breast cancer (TNBC) cells bearing constitutively active STAT3 [53]. Here, GRN is linked to triple-negative breast carcinoma.