The situation was similar in the IGROV-1 tumor model, in which PMX increased the ratio by a factor ~1.5 at 4 h p.i. and by a factor of 1.4–1.6 at 24 h p.i. It was revealed that the distribution of the albumin-binding [177Lu]folate benefited from an additional injection of PMX, 3 h or 7 h after the administration of the radiofolate, in order to further reduce the renal uptake and, therewith, increase the tumor-to-kidney ratios. This evidence concerns the gene ALB and neoplasm.