Nonetheless, a non-significant progressive decline in adiponectin can be observed in previously studied high BMI adolescent girls (>95th percentile for age; adiponectin 6.6 ± 3.0 mg/mL) [8,16,27] as compared to N-BMI-HF and N-BMI-NF adolescents, indicating the metabolic role of this adipokine in obesity-related disease. The gene discussed is ADIPOQ; the disease is hydrops fetalis.