It would be interesting to define the role of endothelial TRPV channels in angiogenesis and carcinogenesis as recent published data implies that TRPV3, TRPV4, TRPV5, TRPM4 and TRPC6 may be thought of as potential genes contributing to colorectal cancer tumorigenesis [50]. The gene discussed is TRPV4; the disease is colorectal cancer.