TRPV1 and inflammation: Furthermore, TRPV1 is implicated in neurogenic inflammation, a process which involves perception of pain and both vasodilation and plasma extravasation aroused from the release of two vasoactive neuropeptides, calcitonin gene-related polypeptide (CGRP) and substance P (SP), from a subpopulation of peptidergic neurons which highly express TRPV1 [5].