As an example, in a large cohort of old men (3384 men, 70–89 years, followed for 7.0 years), elevated levels of P1NP and the ucOC/OC (expressed as %) were associated with higher incidence of MI, although not of stroke, whereas CTx was not associated with incident myocardial infarction or stroke [74]. This evidence concerns the gene CYP27A1 and stroke disorder.