It has been reported that LRP1 depletion in GSVs substantially affects the sorting of GLUT4 to the plasma membrane in 3T3-L1 adipocytes and adipose-specific LRP1 knock-out mice [59], with this event involving the insulin resistance and increased blood glucose levels occurring during MetS and T2DM [10,16]. Here, LRP1 is linked to type 2 diabetes mellitus.