APOE and hepatocellular carcinoma: Immunofluorescence studies have indicated that LRP1 mediates the accumulation of apoE in early (early endosome antigen 1 (EEA1)-positive) endosomes in human hepatoma cells [30], with the apoE processing being different from other LRP1 ligands such as receptor-associated protein (RAP) and activated α2-macroglobulin, which are directly targeted to lysosomal compartments [31].