CCR7 and atherosclerosis: In contrast to the LRP1 role in the development of atherosclerosis, a recent study has revealed that mice macrophage LRP-1 deficiency can also accelerate atherosclerosis regression, since regressing plaques showed a marked transition from M1 to M2 macrophage status, an enhanced reverse cholesterol transport, and an increased expression of CCR7, which promoted macrophage egress from atherosclerotic lesions [70].