Inhibition of MEK, by cobimetinib (at 5 mg/kg, daily), or induction of shRNAs against MAPK7 resulted in tumor growth inhibition, however the combination resulted in improved tumor growth inhibition, demonstrating in vivo validation of our in vitro findings (Fig 5C; shRNAs against NTCs as well as individual tumor plots shown in S5 Fig). This evidence concerns the gene MAP2K7 and neoplasm.