The network analyses further demonstrated the activation of heat shock protein 70 (HSP70) in HPK-IR cells (S1C Fig) and the downregulation of heat shock protein 90 (HSP90) and the proinflammatory cytokine high mobility group box 1 (HMGB1) [46–48] in HPK-(IR)-BS cells (S1D Fig). This evidence concerns the gene HMGB1 and Bloom syndrome.