However, in breast cancer, the function of Malat1 is currently in dispute; recent studies have supplied evidence describing potential mechanisms for Malat1 to function as a tumor suppressor gene by inhibiting EMT through suppression of the PI3K-AKT pathway [11], inactivation of ERK/MAPK signaling [25], or dampening CD133 expression [26]. This evidence concerns the gene PROM1 and neoplasm.