Moreover, relative early onset (early 40 ́s to early 50 ́s) of cataracts (which is a relative frequent feature of RP) [54,55], with no differences between the three groups, but later than that reported for non-p.(Cys759Phe) USH2A patients (30 ́s) [15], again supports that p.(Cys759Phe) is responsible for a milder phenotype than other USH2A variants. This evidence concerns the gene USH2A and retinitis pigmentosa 1.