Previous genome-wide sequencing studies of Wilms tumours, which have targeted high risk blastemal tumours [10] and relapsed or anaplastic tumours [9, 13], did not reveal any germline TRIM28 variants in Wilms tumours although a single somatic TRIM28 splice-site mutation has been detected in a TP53-mutated tumour with diffuse anaplastic histology [13]. Here, TRIM28 is linked to Wilms tumor.