SIX2 and neoplasm: Whole-exome sequencing of 37T and W117 revealed no somatic mutations of other genes known to be mutated in Wilms tumour, including WT1, AMER1, CTNNB1, DROSHA, DGCR8, SIX1, SIX2 and REST. Indeed, no additional missense or non-functional mutations that passed standard filtering criteria were detectable in any other gene in these tumours.