Using an exome-sequencing-based analysis, there were no meaningful structural changes in these tumours except, in one case, copy-neutral loss of heterozygosity at 19q13.43 which encompasses TRIM28. The absence of other identifiable genomic changes in two TRIM28-inactivated tumours suggests that loss of TRIM28 might be the sole driver of tumorigenesis. Here, TRIM28 is linked to neoplasm.