PRKN and Parkinson disease: For example, RanBP2 is implicated in many neurological conditions including Familial acute necrotizing encephalopathy (https://www.targetvalidation.org/target/ENSG00000153201/associations?view=t:table) caused by missense mutations, Parkinson’s disease due to its direct binding of the Parkin protein [77], and potentially Amyotrophic Lateral Sclerosis for which similar symptoms are achieved by RanBP2 knockout in mice [78].