Therefore, to clarify the effects of MK-0677 on Aβ and Aβ-induced pathogenesis, we aimed to test the efficacy of the ghrelin agonist MK-0677 on AD pathology, including Aβ accumulation, neurodegeneration, and neuroinflammation in mice at the early phase of AD through histological quantification analyses. This evidence concerns the gene GHRL and Alzheimer disease.