IL6 and edema: In particular, essential oil (EO) from sour orange (Citrus aurantium L.)has been recently reported to inhibit NO, IL-6, TNF-α, and IL-1β production, as well as their gene expression level in LPS-stimulated RAW264.7 cells [54], while anti-inflammatory properties of EO from taxonomically close related bergamot (Citrus bergamia Risso) have been demonstrated in vivo using the carrageenan-induced rat paw oedema test [25].