However, previous findings identified a specific role for the mammalian N-end rule enzyme UBR5 in degrading the gluconeogenic enzyme PCK1 under high-glucose conditions (Jiang et al., 2011) and a MAGE-TRIM28 E3 ligase complex targeting FBP1 for proteolytic degradation in a hepatocellular cancer background (Jin et al., 2017). The gene discussed is PCK1; the disease is hepatocellular carcinoma.