PDCD1 and graft versus host disease: In experimental animals transplanted with HSC after myeloablative treatment, PD-1 was shown to contribute to the suppression of T cell-mediated GVHD, and PD-1 blockade was associated with an increased glycolytic metabolism in GVHD T cells (Saha et al., 2013; Fujiwara et al., 2014).