NF‐κB activation includes phosphorylation of its inhibitor by IKK (inhibitor kappa B kinase) resulting in IκBα ubiquitization and degradation releasing phopspho‐NF‐κB to translocate to the nucleus where it transcriptionally activates its target genes.18 NF‐κB is the first signalling pathway responding to harmful cellular stimuli, with fairly rapid alterations in gene expression, associated with pro‐tumorigenic events in cancers related to chronic inflammation.20, 21 The most important mechanism in which NF‐κB takes part in tumorigenesis is induction of anti‐apoptotic gene expression.22 This evidence concerns the gene NFKB1 and cancer.