The crucial role of NF‐κB, as link between inflammatory and neoplastic events in epithelial cells, has been mechanistically linked to head and neck and other cancers.18, 19 NF‐κB is a transcriptional factor consisting of five subunits, RELA(p65), RELB, NFkB1, NFkB2 and c‐REL, and their heterodimeric complexes. This evidence concerns the gene RELA and cancer.