There is evidence that in head and neck cancer, the NF‐κB transcriptional factor is constitutively activated and linked to activation of known oncogenic pathways, such EGFR/Ras/RAF/MAPK, Akt/PI3K/mTOR, ΙΚΚ/NF‐κB, STAT3 and wnt/β‐catenin.32, 33, 34, 35, 36, 37, 38, 39, 40, 41. This evidence concerns the gene AKT1 and head and neck cancer.