This study may support an intriguing possibility that the lack of TRIM67 may result in the onset of neurologic dysfunction with age, a common feature of many human disorders including schizophrenia, bipolar disorder, and neurodegenerative diseases (Larson and Nyman, 1970; Häfner et al., 1994; Carlson et al., 2002). Here, TRIM67 is linked to bipolar disorder.