SIPA1L2 and early-onset autosomal dominant Alzheimer disease: The proximity of TRIM67 to other genes linked to Alzheimer’s disease and schizophrenia (DISC1; Beecham et al., 2009; Carless et al., 2011), Parkinson’s disease (SIPA1L2; Nalls et al., 2014), and cognitive function (DISC2, C1orf131, GALNT2; Xu et al., 2017) by genome-wide association studies (GWAS), and the behavioral deficits revealed here associated with deletion of murine Trim67 are intriguing, potentially suggesting possible involvement of TRIM67 in human disorders or behaviors.