In this study, we focused on drainage-resistant Klebsiella pneumoniae liver abscesses (DRKPLAs), and they had the following features: (a) the maximum diameter of the abscess did not decrease 1 week after drainage, and the drainage tube position was located within the lesion (Figures 1A,B); (b) the patients still exhibited a high fever, chills and other symptoms, and the inflammation did not decrease as indicated, for example, by the failure of C-reactive protein (CRP) levels or decrease in white blood cell counts. This evidence concerns the gene CRP and Liver abscess.