FASN and posterior cortical atrophy: For example, in PCa cells, ASC-J9 was able to suppress expression fatty acid synthase that stimulates PCa cell growth and invasion (46) or to inhibit the phosphorylation of STAT3 that promotes PCa stem/progenitor cells invasion (39); in the cells of the tumor microenvironment, ACS-J9 could suppress the CD4+ T cell migration that contribute to the progression of prostatitis (47), or the macrophage infiltration that stimulated PCa cell invasion (38).