High levels of circulating fetuin-A are associated with insulin resistance (IR) (Mori et al., 2006; Stefan et al., 2006; Reinehr & Roth, 2008; Ali, Nassif & Abdelaziz, 2016), and a higher fetuin-A level is associated with a higher risk of diabetes (Aroner et al., 2017). This evidence concerns the gene AHSG and Insulin resistance.