ERBB2 and neoplasm: In patients treated with NSM, Petit et al [38] indeed showed, in 2012, that risks of recurrences in the breast included high grade tumours, overexpression/amplification of HER2/neu and molecular subtype luminal B. In the nipple areola complex, the corresponding risk factors were age <45 years, absence of oestrogen receptors, high grade tumours, and HER2/neu overexpression and high Ki-67.