CRP has also been shown to attenuate leptin signaling in cells overexpressing Ob R (36), however it was not clear whether this was a result of binding with leptin or a direct effect of CRP on Ob R. Therefore, in the present study we have examined the possible interaction of CRP with the leptin receptor and its implication in obesity. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.