CD226 and colorectal carcinoma: Among a panel of 14 cell lines (see Materials and Methods), all reacting with Fc-DNAM1 chimera and all but T84 and Colo205 cell lines, with Fc-NKG2D chimera (Figure S2 in Supplementary Material) we chose the three representative CRC cell lines Caco2, HCT15, and SW480 expressing the adhesion molecule ICAM1 (Figure S2 in Supplementary Material) and the ligands of NKG2D (MICA and ULBPs) and DNAM1 activating receptors (PVR, Figure S3 in Supplementary Material).