As shown in Figure 6B, NKp46+CD3− cells derived from four out of five CRC specimens could be elicited to activate ATCC via CD16, NKp46, DNAM1, and NKG2D (the anti-CD3 mAb used as negative control did not increase the spontaneous activity, identified as CTR in the figure), indicating that this cell population is potentially cytotoxic. The gene discussed is FCGR3A; the disease is colorectal carcinoma.