CD226 and colorectal carcinoma: As shown in Figure 6B, NKp46+CD3− cells derived from four out of five CRC specimens could be elicited to activate ATCC via CD16, NKp46, DNAM1, and NKG2D (the anti-CD3 mAb used as negative control did not increase the spontaneous activity, identified as CTR in the figure), indicating that this cell population is potentially cytotoxic.