We found that IL-2-activated NK cells derived from co-cultures with tumor-derived MSC (NK/TAF) exerted lower cytotoxicity of Caco2, HCT15, and SW480 CRC cell lines, compared to NK cells cultured with IL-2 alone that were efficiently able to lyse CRC (Figures 1A–C, NK/TAF vs NK in each panel). This evidence concerns the gene IL2 and colorectal carcinoma.