Young age, gross complete tumor resection, neuronavigation with 5 Ala, Gradel (BCNU waffle), irradiation, CCRT, IDH-1 mutation, methylated MGMT, TMZ, Avastin, and immunotherapy (2, 4, 6, 65, 66) have all been studied and may improve the tumor control. This evidence concerns the gene IDH1 and neoplasm.