Of interest, despite the negative finding with respect to the role of YXQNW and SC in attenuating hypercholesterolemia, both drugs were found to alleviate the cognitive impairment of LDLR (+/-) golden Syrian hamsters, implying the occurrence of a mechanism other than lowering plasma cholesterol that mediates the effect of the two drugs on cognitive impairment in the current circumstance. The gene discussed is LDLR; the disease is familial hypercholesterolemia.