Interestingly, we also show that activation of Adora2b modulates expression of Tgm2, a multifunctional enzyme (Gundemir et al., 2012; Eckert et al., 2014; Liu et al., 2017) that has been associated with PH (Diraimondo et al., 2014; Penumatsa et al., 2017) and pulmonary fibrosis (Oh et al., 2011; Olsen et al., 2011, 2014). Here, TGM2 is linked to pulmonary fibrosis.