In experiments using pulmonary artery smooth muscle cells (PASMC), studies have shown that activation of ADORA2B can lead to increased expression of hyaluronan synthase (HAS) isozymes 1 and 2, enhancing levels of hyaluronan (Karmouty-Quintana et al., 2013a), the major glycosaminoglycan in the lungs that when fragmented has been implicated in modulating PH and lung fibrosis (Karmouty-Quintana et al., 2013a; Collum et al., 2017b). Here, ADORA2B is linked to pulmonary fibrosis.