In addition to these meditators, we also report the novel finding that Tgm2 can be modulated by Adora2b and that this is consistent with increased expression of vascular Tgm2 in experimental models of PH and in remodeled vessels of patients with a diagnosis of PAH or IPF+PH. The gene discussed is ADORA2B; the disease is idiopathic pulmonary fibrosis.