It has been reported that repeated applications of DNCB to the skin of NC/Nga mice induced AD-like skin lesions, which is associated with an increase in serum immunoglobulin (Ig) E and T-helper (Th) 2 cytokines such as interleukin (IL)-4, IL-5, and IL-13 at the chronic dorsal skin lesions (Choi et al., 2012). Here, IL4 is linked to Alzheimer disease.