We found that, compared with WT mice, 3×Tg AD mice had lower levels of ADAM10, sAPPα, and C83 in the hippocampus of, while fluoxetine treatment markedly enhanced the expression of ADAM10, sAPPα, and C83 in the hippocampus of 3×Tg AD mice. The gene discussed is ADAM10; the disease is Alzheimer disease.