In this study, we chose MPTP/p insulted mouse model other than other PD mouse models including BAC-α-Syn-GFP transgenic mice, Pitx3-mutant model mice, and MPTP -acute or sub-acute mouse model, since probenecid slows down the clearance of MPTP and entends duration of DA neurons damage; hereby it imitates most of behavioral symptoms and pathological changes in PD (Binukumar et al., 2015; Zhang et al., 2016b; Brandt et al., 2017; Zhao et al., 2017; Zhong et al., 2017). This evidence concerns the gene PITX3 and Parkinson disease.