Here, we want to evaluate the effect of Cdk5 inhibition by CIP in an MPTP/p induced PD mouse model, in which daily MPTP injection was for 10 days and probenecid was injected over 5 weeks (twice per week) to block the rapid clearance of MPTP toxin and its metabolites (Gonçalves, 2005). This evidence concerns the gene CDK5 and Parkinson disease.