In humans, patients with GLRA1 mutations suffer from neonatal hypertonia, an exaggerated startle reflex in response to tactile or acoustic stimuli and in some instances in life-threatening infantile apnea episodes immediately after birth arguing for a developmental switch of GlyR α2 to α1 subunits around birth (Davies et al., 2010). This evidence concerns the gene GLRA1 and Apnea.