A systematic review of randomized controlled trials (RCTs) investigating the effects of exercise on BNP and NT-proBNP in patients with heart failure showed that aerobic and resistance training had a favorable effect on NPs and decreased BNP levels (mean difference −79 pg/mL; 95% confidence intervals (CI), −141 to −17 pg/mL) and NT-proBNP levels (mean difference −621 pg/mL; 95% CI, −844 to −398 pg/mL) [20]. Here, NPPB is linked to heart failure.