One individual with colorectal adenocarcinoma at age 50 years and breast cancer at 57 years carried a PMS2 frameshift variant (c.741−742insTGAAG [p.Pro247_Ser248fs] [Ensembl: ENST00000265849; GenBank: NM_000535.6]) and a BMPR1A nonsense variant (c.730C>T [p.Arg244∗] [Ensembl: ENST00000372037; GenBank: NM_004329.2]). The gene discussed is PMS2; the disease is colorectal adenocarcinoma.