GLA and Fabry disease: Anderson-Fabry disease (AFD) is an X-linked lysosomal storage disorder caused by mutations in the GLA gene that result in deficiency of the enzyme α-galactosidase A. The worldwide incidence of Fabry’s disease is reported to be in the range of 1 in 40,000–117,000, although this value may be a significant underestimate given under recognition of symptoms and delayed or missed diagnosis (Zarate and Hopkin 2008; Mehta et al. 2004).