We have explored the associations of NOS3 SNPs with MetS risk in the context of SCH, but similar findings related to the T-786C mutant allele and MetS risk were found in studies in patients with different non-psychiatric disorders, in particular ischemic and non-ischemic cardiomyopathy, hypertension and T2DM [32–34]. Here, NOS3 is linked to Hypertension.