TERT and hepatocellular carcinoma: Driver mutations involved in HCC progression were identified in the promoter of the telomerase reverse transcriptase (TERT) gene (in 60% of cases), in CTNNB1 (11–37%), which is part of the WNT pathway, in TP53 (10–30%), and in CDKN2A (2–12%), which has a role in the regulation of the cell cycle in G1 and G2 phases8.