At present, it is unclear how c-Myc expression is enhanced in CRLF2/JAK2 mutant B-ALL cells with sustained depletion/inhibition of JAK2; this remains to be elucidated in future studies, but the response did not appear to be driven by transcriptional up-regulation of c-Myc expression. Here, CRLF2 is linked to acute lymphoblastic leukemia.