It is possible that post-translational modifications of c-Myc, including phosphorylation, acetylation, and/or ubiquitination (Li et al. 2001; Adhikary and Eilers 2005; Faiola et al. 2005), may have contributed to its increased expression in CRLF2/JAK2 mutant B-ALL cells with sustained depletion or inhibition of JAK2 through one or more of the various signal transduction pathways that are known to regulate c-Myc expression (Vervoorts et al. 2006). Here, CRLF2 is linked to acute lymphoblastic leukemia.