Finally, transcriptome-wide analysis using a larger c-Myc target gene set (HALLMARK_MYC_TARGETS_V1) revealed that the expression of a large number of these genes displayed enhanced expression in Eμ-Crlf2/Jak2R683G B-ALL cells with sustained (chronic) Jak2 depletion (Fig. 5E). The gene discussed is JAK2; the disease is acute lymphoblastic leukemia.