Importantly, we have found a significant correlation between the phosphorylation of p38α in monocytes/macrophages and the phosphorylation of IGF‐1 receptor both in colon samples from ulcerative colitis patients and in tumor samples from colon cancer patients (Fig 8A–E), supporting the potential clinical relevance of the p38α/IGF‐1 axis in human disease. This evidence concerns the gene IGF1 and colonic neoplasm.