IGF1 and colitis: We observed lower IL‐4 expression in p38α‐ΔMC mice compared to WT mice, both during DSS‐induced colitis and in the tumors, and given that IL‐4 is a major IGF‐1 inducer, it could further contribute to the decreased levels of IGF‐1 signaling in p38α‐ΔMC mice.