CD28 and congenital rubella syndrome: Subsequently, CRS has been described after infusion of several antibody-based therapies such as anti-thymocyte globulin (ATG) [3], the CD28 superagonist TGN1412 [4], rituximab [5], obinutuzumab [6], alemtuzumab [7], brentuximab [8], dacetuzumab [9], and nivolumab [10].