Since secondary hyperparathyroidism (SHPT) characterized by persistent elevated parathyroid hormone (PTH) and marked parathyroid hyperplasia is the leading cause of osteitis fibrosa cystica [8], the current recommended treatment for renal osteodystrophy is to manage secondary hyperparathyroidism, but not typical osteoporosis therapies. The gene discussed is PTH; the disease is renal osteodystrophy.