Two cell lines of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) had high levels of NF-κB DNA-binding activity in the nucleus, constitutive IKK activity, and rapid IκB degradation that were not observed in germinal center B cell-like diffuse large B cell lymphoma (GCB-DLBCL) [11], demonstrating the key role of NF-κB activity in the proliferation of various subtypes of lymphoma cells. This evidence concerns the gene NFKB1 and lymphoma.