ATP6V0C and neurodegenerative disease: Interestingly, its top hub is Atp6v0c, a gene that encodes a component of vacuolar ATPase, a multisubunit enzyme that is necessary for intracellular processes receptor-mediated endocytosis and synaptic vesicle proton gradient generation (Lee et al., 2010), and has been described to alter autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease (Mangieri et al., 2014) and has been proposed as a possible target gene for therapy (Higashida et al., 2017).