Its top hub gene Ttbk1(tau tubulin kinase 1), whose encoded protein is a neuron-specific serine/threonine and tyrosine kinase that regulates phosphorylation of tau, has been implicated in both the pathology of amyotrophic lateral sclerosis (Liachko et al., 2014) and AD (Vázquez-Higuera et al., 2011). This evidence concerns the gene MAPT and Alzheimer disease.