Furthermore, in addition to glucose usage, the expression of metabolic enzymes has been shown to be disrupted in neurodegenerative conditions; reduced expression of α-glucosidase—the enzyme that degrades glycogen to glucose—is observed in laser-captured motor neurons from post-mortem ALS spinal cords [7], and glucose-6-phosphate isomerase (Gpi1) (also termed GPI in human, phosphoglucose isomerase (PGI), neuroleukin (NLK), or autocrine motility factor (AMF)) is upregulated in the brain of a mouse model of HD [8]. This evidence concerns the gene GPI and amyotrophic lateral sclerosis.